Fig. 5. CDX2 attenuates the activity of the Wnt/β-catenin pathway in colorectal carcinogenesis.
a, b The luciferase reporter activities in CDX2-knockdown and CDX2-overexpressing HT-29 (a) or Caco-2 (b) cells transfected with a TOP/FOP-Flash reporter plasmid. c, d Western blot bands of cyclin D1, c-myc, and β-catenin in CDX2-knockdown and CDX2-overexpressing HT-29 (c) and Caco-2 (d) cells. All data are the mean ± SD of three independent experiments. *P < 0.05