Fig. 2.

Efficacy of the PE and PF cocktails against EBOV Makona. a Binding of the indicated antibodies to V82 GP variant as percentage of binding to A82 Makona GP. b Relative binding of the indicated mAbs to Makona quasispecies compared to wt. c–f Efficacy of PE (n = 5) and PF (n = 5) cocktails in NHP model of EBOV Makona infection. g–j Viral loads in blood, as well as oral, nasal, and rectal swabs. k–n Select hematology and blood chemistry data at various times post challenge. PLT platelets, ALT alanine transaminase, TBIL total bilirubin, BUN blood urea nitrogen. Statistical analysis of survival was performed by log-rank test