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. 2019 Jan 10;9:26. doi: 10.1038/s41598-018-37176-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival of MRC-5 fibroblasts after two days of infection with M. tuberculosis in the presence of various concentrations of eburnamonine. The viability of MRC-5 fibroblasts was determined by resazurin conversion assay (see materials and methods). The viability of MRC-5 fibroblasts that were exposed to avirulent M. tuberculosis H37Ra was set to 100% (upper dotted line) and the rest of the samples were normalized accordingly. In the absence of any compounds, exposure to virulent H37Rv results in 33% viability compared to H37Ra exposure (lower dotted line). The bar graph was plotted based on average and standard deviation values obtained from at least four independent replicates.