Table 2.
Parameters, scores, distribution of specimens, medians and interquartile ranges of attributed scores according to histopathological analysis at 28 postoperative days after tooth extraction in VEH, VEH-PRP, ZOL and ZOL-PRP groups.
| Histopathological Analysis | ||||
|---|---|---|---|---|
| Parameters and Respective Scores | Number of Specimens | |||
| Experimental Groups | ||||
| VEH (n = 7) | VEH-PRP (n = 7) | ZOL (n = 7) | ZOL-PRP (n = 7) | |
| Intensity of Local Inflammatory Response | ||||
| (1) absence of inflammation | 7 | 7 | — | 4 |
| (2) small quantity of inflammatory cells | — | — | — | 3 |
| (3) moderate quantity of inflammatory cells | — | — | 3 | — |
| (4) large quantity of inflammatory cells | — | — | 4 | — |
| medians and interquatile ranges | 1 (1–1) |
1 (1–1) |
4†,‡ (3–4) |
1¶ (1–2) |
| Inflammation Extension | ||||
| (1) absence of inflammation | 7 | 7 | — | 4 |
| (2) partial extension of connective tissue | — | — | — | 3 |
| (3) entire extension of connective tissue, without reaching bone tissue | — | — | 2 | — |
| (4) entire extension of connective tissue and bone tissue | — | — | 5 | — |
| medians and interquatile ranges | 1 (1–1) |
1 (1–1) |
4†,‡ (3–4) |
1¶ (1–2) |
| Cellular Pattern and Epithelial Tissue Structure | ||||
| (1) moderate layer of epithelial tissue completely recovering extraction site | 4 | 5 | — | 3 |
| (2) thin layer of epithelial tissue completely recovering extraction site | 3 | 2 | — | 4 |
| (3) thin layer of epithelial tissue only in edges of open surgical wound | — | — | 4 | — |
| (4) absence of epithelial tissue on open surgical wound | — | — | 3 | — |
| medians and interquatile ranges | 1 (1–2) |
1 (1–2) |
3†,‡ (3–4) |
2¶ (1–2) |
| Cellular Pattern and Connective Tissue Structure | ||||
| (1) moderate quantity of fibroblasts and large quantity of collagen fibers | 4 | 5 | — | 3 |
| (2) moderate quantity of both fibroblasts and collagen fibers | 3 | 2 | — | 4 |
| (3) small quantity of both fibroblasts and collagen fibers | — | — | 2 | — |
| (4) severe tissue disorganization with necrosis areas | — | — | 5 | — |
| medians and interquatile ranges | 1 (1–2) |
1 (1–2) |
4†,‡ (3–4) |
2¶ (1–2) |
| Cellular Pattern and Bone Tissue Structure | ||||
| (1) absence of non-vital bone in tissues adjacent to the extraction site and trabecular bone filling more than half of extraction socket | 6 | 7 | — | 4 |
| (2) absence of non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than half of extraction socket | 1 | — | — | 2 |
| (3) presence of few areas with non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than a third of extraction socket | — | — | 2 | 1 |
| (4) presence of many areas with non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than a third of extraction socket | — | — | 5 | — |
| medians and interquatile ranges | 1 (1–2) |
1 (1–1) |
4†,‡ (3–4) |
1¶ (1–3) |
| Contamination Pattern of Tooth Extraction Site | ||||
| (1) presence of bacteria diffusely distributed in extraction site, typical of a normal condition | 7 | 7 | — | 4 |
| (2) presence of large colonies of bacteria in soft tissues over extraction socket | — | — | — | 2 |
| (3) presence of large colonies of bacteria in surface of alveolar bone and in the interior of the extraction socket | — | — | — | 1 |
| (4) presence of large colonies of bacteria involving necrosed bone and/or in medullar spaces and in tissues adjacent to the extraction socket | — | — | 7 | — |
| medians and interquatile ranges | 1 (1–1) |
1 (1–1) |
4†,‡ (4–4) |
1¶ (1–3) |
Symbols: †Statistically significant difference in relation to VEH; ‡Statistically significant difference in relation to VEH-PRP; ¶Statistically significant difference in relation to ZOL.