Table 1.
Top 20 up- and down-regulated proteins in 3Tg-iAstro compared to WT-iAstro lines
| Uniprot_ID | Description | Fold change | P value |
|---|---|---|---|
| Top 20 of UP-regulated proteins | |||
| CALM_MOUSE | Calmodulin OS = Mus musculus GN = Calm1 PE = 1 SV = 2 | 3.57 | 0.00067 |
| ACTG_MOUSE | Actin, cytoplasmic 2 OS = Mus musculus GN = Actg1 PE = 1 SV = 1 | 3.46 | 0.00229 |
| EZRI_MOUSE | Ezrin OS = Mus musculus GN = Ezr PE = 1 SV = 3 | 3.16 | 0.00189 |
| PUR4_MOUSE | Phosphoribosylformylglycinamidine synthase OS = Mus musculus GN = Pfas PE = 2 SV = 1 | 3.16 | 0.00287 |
| ACTB_MOUSE | Actin, cytoplasmic 1 OS = Mus musculus GN = Actb PE = 1 SV = 1 | 3.10 | 0.00358 |
| MAOM_MOUSE | NAD-dependent malic enzyme, mitochondrial OS = Mus musculus GN = Me2 PE = 2 SV = 1 | 2.86 | 0.01149 |
| APMAP_MOUSE | Adipocyte plasma membrane-associated protein OS = Mus musculus GN = Apmap PE = 1 SV = 1 | 2.66 | 0.04597 |
| VDAC1_MOUSE | Isoform Mt-VDAC1 of Voltage-dependent anion-selective channel protein 1 OS = Mus musculus GN = Vdac1 | 2.58 | 0.04867 |
| MYH10_MOUSE | Myosin-10 OS = Mus musculus GN = Myh10 PE = 1 SV = 2 | 2.35 | 0.01125 |
| XPO1_MOUSE | Exportin-1 OS = Mus musculus GN = Xpo1 PE = 1 SV = 1 | 2.16 | 0.01711 |
| MYADM_MOUSE | Myeloid-associated differentiation marker OS = Mus musculus GN = Myadm PE = 2 SV = 2 | 2.15 | 0.03671 |
| MCA3_MOUSE | Eukaryotic translation elongation factor 1 epsilon-1 OS = Mus musculus GN = Eef1e1 PE = 2 SV = 1 | 1.95 | 0.03302 |
| KCRB_MOUSE | Creatine kinase B-type OS = Mus musculus GN = Ckb PE = 1 SV = 1 | 1.80 | 0.04875 |
| HMOX1_MOUSE | Heme oxygenase 1 OS = Mus musculus GN = Hmox1 PE = 1 SV = 1 | 1.80 | 0.01236 |
| FERM2_MOUSE | Fermitin family homolog 2 OS = Mus musculus GN = Fermt2 PE = 1 SV = 1 | 1.80 | 0.02534 |
| GLRX3_MOUSE | Glutaredoxin-3 OS = Mus musculus GN = Glrx3 PE = 1 SV = 1 | 1.60 | 0.03293 |
| ADT1_MOUSE | ADP/ATP translocase 1 OS = Mus musculus GN = Slc25a4 PE = 1 SV = 4 | 1.58 | 0.00764 |
| IF4H_MOUSE | Eukaryotic translation initiation factor 4H OS = Mus musculus GN = Eif4h PE = 1 SV = 3 | 1.55 | 0.00594 |
| IF5A1_MOUSE | Eukaryotic translation initiation factor 5A-1 OS = Mus musculus GN = Eif5a PE = 1 SV = 2 | 1.50 | 0.03688 |
| FSCN1_MOUSE | Fascin OS = Mus musculus GN = Fscn1 PE = 1 SV = 4 | 1.47 | 0.02807 |
| Top 20 of DOWN-regulated proteins | |||
| K2C1B_MOUSE | Keratin, type II cytoskeletal 1b OS = Mus musculus GN = Krt77 PE = 1 SV = 1 | −4.89 | 0.02491 |
| RABP1_MOUSE | Cellular retinoic acid-binding protein 1 OS = Mus musculus GN = Crabp1 PE = 1 SV = 2 | −3.96 | 0.00811 |
| RANG_MOUSE | Ran-specific GTPase-activating protein OS = Mus musculus GN = Ranbp1 PE = 1 SV = 2 | −3.15 | 0.000058 |
| MYEF2_MOUSE | Myelin expression factor 2 OS = Mus musculus GN = Myef2 PE = 1 SV = 1 | −2.76 | 0.00512 |
| RL5_MOUSE | 60S ribosomal protein L5 OS = Mus musculus GN = Rpl5 PE = 1 SV = 3 | −2.36 | 0.00058 |
| RS30_MOUSE | 40S ribosomal protein S30 OS = Mus musculus GN = Fau PE = 1 SV = 1 | −2.33 | 0.01976 |
| DDX17_MOUSE | Probable ATP-dependent RNA helicase DDX17 OS = Mus musculus GN = Ddx17 PE = 1 SV = 1 | −2.25 | 0.0443 |
| KPYM_MOUSE | Isoform M1 of pyruvate kinase PKM OS = Mus musculus GN = Pkm | −2.21 | 0.01086 |
| MIF_MOUSE | Macrophage migration inhibitory factor OS = Mus musculus GN = Mif PE = 1 SV = 2 | −2.13 | 0.04215 |
| K22E_MOUSE | Keratin, type II cytoskeletal 2 epidermal OS = Mus musculus GN = Krt2 PE = 1 SV = 1 | −2.06 | 0.04617 |
| ANXA6_MOUSE | Annexin A6 OS = Mus musculus GN = Anxa6 PE = 1 SV = 3 | −2.05 | 0.01972 |
| S10A6_MOUSE | Protein S100-A6 OS = Mus musculus GN = S100a6 PE = 1 SV = 3 | −2.02 | 0.00021 |
| BTF3_MOUSE | Isoform 2 of transcription factor BTF3 OS = Mus musculus GN = Btf3 | −2.02 | 0.00144 |
| SARNP_MOUSE | SAP domain-containing ribonucleoprotein OS = Mus musculus GN = Sarnp PE = 1 SV = 3 | −2.01 | 0.03162 |
| RL19_MOUSE | 60S ribosomal protein L19 OS = Mus musculus GN = Rpl19 PE = 1 SV = 1 | −1.92 | 0.0261 |
| HNRPM_MOUSE | Heterogeneous nuclear ribonucleoprotein M OS = Mus musculus GN = Hnrnpm PE = 1 SV = 3 | −1.89 | 0.00045 |
| ENPL_MOUSE | Endoplasmin OS = Mus musculus GN = Hsp90b1 PE = 1 SV = 2 | −1.85 | 0.01527 |
| RS15_MOUSE | 40S ribosomal protein S15 OS = Mus musculus GN = Rps15 PE = 2 SV = 2 | −1.84 | 0.00744 |
| RL13_MOUSE | 60S ribosomal protein L13 OS = Mus musculus GN = Rpl13 PE = 2 SV = 3 | −1.83 | 0.03011 |
| EF1D_MOUSE | Elongation factor 1-delta OS = Mus musculus GN = Eef1d PE = 1 SV = 3 | −1.80 | 0.03256 |