Fig. 7. miR-1254 inhibited tumorigenicity in vivo.

a, d Xenograft tumors were obtained from different groups of nude mice transfected with miR-NC, miR-1254-mimics, and miR-1254-inhibitor, respectively. b, c, e, f Tumor growth curve and tumor weight were significantly different between miR-1254-mimics or miR-1254-inhibitor and corresponding control group. g The expression levels of miR-1254 in the implanted tumors that were transfected with miR-1254-mimics and miR-1254-inhibitor were explored by miRNA RT-PCR. h and i The expression of Smurf1 protein level were determined by western blot. *p < 0.05; **p < 0.01; ***p < 0.001. The data expressed as the mean ± SD