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. 2019 Jan 9;8(1):5. doi: 10.1038/s41389-018-0113-z

Fig. 2. Mutual exclusivity between the expression of FAM171A1 and ESR1 (ERα) in breast cancer.

Fig. 2

a Expression of FAM171A1 and ESR1 (ERα) in METABRIC (n = 2051) and TCGA (n = 1084) databases analyzed by cBioPortal tool. b Scatter plot analysis of ESR1 (ERα) and FAM171A1 mRNA expression using cBioPortal; Pearson correlation: 0.394; Spearman: −0.578. c Boxplots showing the mRNA expression of FAM171A1 in three Oncomine datasets stratified based on ERα positive and ERα negative status; TCGA (n = 593), Curtis (n = 2136), and Hatzis (n = 508); datasets ordered by overexpression Gene Rank; top 10%, a threshold at p-value = 1E−4. d, e Western blot analysis showing the effect of overexpression of ERα on FAM171A1 in MDAMB231 cells cultured in both FBS containing DMEM media and CTS containing phenol-red free DMEM. Experiments (d, e) were performed three times with similar results