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. 2018 Sep 8;151(1):5–20. doi: 10.1007/s00418-018-1719-0

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — ISH staining of MGL mRNA (FastRed) in ileum of healthy (a, c, e) and LPS-treated (b, d, f) mice. MGL mRNA is equally present in epithelium (ep) and lamina propria (lp) cells of healthy ileum (a) and ileum from LPS-treated mice (b arrows denote representative mRNA staining). Expression is also present in myenteric ganglia (denoted by an asterisk) of healthy (c) and LPS-treated (d) mice. Expression of the MGL gene is widespread in the circular (cm) and the longitudinal muscle layer (lm), (arrows in c), and it is slightly decreased in LPS-treated mice (d). Only low co-localization of MGL gene expression with CD3⁺ cells (purple, VIP) is found in healthy (e) and even lower co-localization in LPS-treated (f) mice. Quantification of MGL/CD3 double staining is shown in g. Calibration bars: 10 µm; cm circular muscle layer, ep epithelium, lp lamina propria, lm longitudinal muscle layer, cl crypt lumen; *, myenteric ganglion