Table 3.
Properties of freeze-dried milk/infant formula-drug tablets with and without the disintegrant, PVPP (Data are mean ± SD, n = 10.
| Lipid source | Amount of drug (mg)/g of fat | Diameter (mm) | Weight (mg) | Thickness (mm) | Tensile strength (MPa) | Friability (%) | Disintegration time (min) |
|---|---|---|---|---|---|---|---|
| Tablets without PVPP | |||||||
| Bovine milk | 66 | 14.00 ± 0.02 | 596 ± 4 | 4.51 ± 0.05 | 1.14 ± 0.02 | 0.6 ± 0.3 | 41.4 ± 1.3 |
| Infant formula | 66 | 14.00 ± 0.01 | 719 ± 3 | 5.50 ± 0.06 | 0.41 ± 0.01 | 2.2 ± 0.1 | 33.3 ± 1.1 |
| Tablets with 30 w/w% PVPP | |||||||
| Bovine milk | 66 | 14.00 ± 0.02 | 777 ± 4 | 7.02 ± 0.07 | 1.04 ± 0.04 | 0.3 ± 0.3 | 21.5 ± 0.9 |
| Infant formula | 66 | 14.00 ± 0.01 | 927 ± 3 | 9.01 ± 0.06 | 0.43 ± 0.05 | 1.9 ± 0.2 | 6.2 ± 0.7 |