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. 2019 Jan 4;8:658. doi: 10.3389/fonc.2018.00658

Table 1.

Intersection of top 10% molecular pathways by average PI and molecular pathways with AUC < 0.7 for all cancer types.

# Pathway name (according to the source pathway database) PI Reference
1 NCI Aurora A signaling Pathway (protein catabolic process) 0.19 http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fpathwaycommons.org%2Fpc2%2FPathway_83968ff327912d4d5a0ee5f31d27adf9
2 biocarta double stranded RNA induced gene expression Main Pathway 0.19 http://amp.pharm.mssm.edu/Harmonizome/gene_set/double+stranded+rna+induced+gene+expression/Biocarta+Pathways
3 biocarta role of BRCA1 BRCA2 and ATR in cancer susceptibility Pathway (DNA replication termination) 0.18 http://amp.pharm.mssm.edu/Harmonizome/gene_set/role+of+brca1+brca2+and+atr+in+cancer+susceptibility/Biocarta+Pathways
4 biocarta p53 signaling Main Pathway 0.18 http://amp.pharm.mssm.edu/Harmonizome/gene_set/p53+signaling+pathway/Biocarta+Pathways
5 NGF Pathway Apoptosis 0.17 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=320
6 BRCA1 Pathway Mismatch Repair 0.16 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=68
7 ATM Pathway G2-Mitosis progression 0.16 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=46
8 ATM Pathway G2 M Checkpoint Arrest 0.16 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=46
9 biocarta tumor suppressor ARF inhibits ribosomal biogenesis Main Pathway 0.16 http://software.broadinstitute.org/gsea/msigdb/cards/BIOCARTA_ARF_PATHWAY
10 biocarta ATM signaling Main Pathway 0.14 http://software.broadinstitute.org/gsea/msigdb/geneset_page.jsp?geneSetName=BIOCARTA_ATM_PATHWAY
11 NCI Hypoxic and oxygen homeostasis regulation of HIF1 alpha Main Pathway 0.12 http://www.pathwaycommons.org/pc/record2.do?id=517145
12 HIF1 Alpha Pathway NOS Pathway 0.11 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=223
13 HIF1Alpha Pathway VEGF Pathway 0.09 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=223
14 HIF1Alpha Pathway Gene Expression via JUN CREB3 0.09 https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=223
15 Lipoxins Influence on Cell Growth and Proliferation 0.05 http://pathwaymaps.com/maps/2690
16 NCI Validated transcriptional targets of TAp63 isoforms Pathway (Pathway degradation of TP63) 0.03 http://www.pathwaycommons.org/pc/record2.do?id=517011
17 NCI Validated transcriptional targets of TAp63 isoforms Pathway (Metastasis) 0.02 http://www.pathwaycommons.org/pc/record2.do?id=517011
18 D-imyoi-inositol 145-trisphosphate biosynthesis 0.02 https://metacyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-6351