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(A) Structural alignment of apo-Myo5b-GTD (PDB ID: 4LNZ) with Myo5b–GTD/Rab11a complex (PDB ID: 4LX0). The two residues (K1701 and K1774) and H11-H12 loop, both critical for the head–GTD interaction of Myo5b, are labeled. (B) Proposed model for the association of Myo5b with vesicles via Rab11a/FIP2 and the activation of Myo5b motor function by Rab11a.
