Mice were grouped as CTL (saline i.g), CLM (2.1 g/kg, i.g), KET (30 mg/kg, i.p) and tested at 30 min and 24 hr post administration. (A) Total distance traveled during a 5-min open field testing time at 30 min after CLM and ketamine administration, P=0.146. (B) Time spent on the center part during a 5-min open field testing time at 30 min after CLM and ketamine administration, P=0.647. (C) Total distance traveled during a 5-min open field testing time at 24 hr after CLM and ketamine administration, P=0.269. (D) Time spent on the center part during a 5-min open field testing time at 24 hr after CLM and ketamine administration, P=0.098. Values represent mean ± S.E.M. Statistical evaluation was performed using multiple comparisons made using one-way ANOVA, followed by the Newman–Keuls multiple range test, and a value of P<0.05 was considered statistically significant. n=10/group.