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. 2019 Jan 10;7(1):e13958. doi: 10.14814/phy2.13958

Figure 5.

Figure 5

Subchronic N‐acetylcysteine (NAC) does not inhibit nicotine reinstatement or t‐SP. (A) Representative micrographs of dendritic spines from animals receiving 0 ( top ) or 100 mg/kg NAC ( bottom ). (B) Self‐administration and extinction of rats receiving either 0 or 100 mg/kg NAC prior to sacrifice for dendritic spine morphology analysis. (C) Total infusions received by group throughout self‐administration. (D) Treatment with 100 mg/kg NAC did not significantly reduce active lever pressing during a 15 min reinstatement session compared to vehicle‐treated animals. (E) High‐dose NAC (100 mg/kg) did not significantly alter mean spine head diameter. No effects of high‐dose NAC (100 mg/kg) were observed on the (F) cumulative frequency distribution of spine neck diameter or spine neck length (I) at T = 15. Comparisons of spine density, mean spine neck length, and head diameter to neck length ratio are shown in (G), (H), and (J), respectively. Dashed line in (G) represents basal (T = 0, vehicle‐treated) levels. *P < 0.05 compared to animals receiving 0 mg/kg NAC in (C). *P < 0.0001 main effect of session (extinction vs. reinstatement) in (D).