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Dysregulated SIRT1 affected the Nrf2/HO-1 and the NF-κB pathways in HaCaT cells. Transfected and untransfected HaCaT cells were stimulated with 10 μg/mL LPS for 12 h. Non-treated cells acted as control. Then, expressions of key kinases in (a) the Nrf2/HO-1 pathway and (b) the NF-κB pathway were evaluated by western blot analysis. Data were presented as the mean ± SEM of three independent experiments. CTRL: control; t-: total; p-: phospho-.
*P < 0.05; **P < 0.01; ***P < 0.001.
