Table 8.
Predictive factors for complete pathological response in univariate logistic regression analysis for the mFOLFOX6-RT regimen
| Variable | Non-pCR (n = 81) n P50 (P25-P75) | pCR (n = 45) n P50 (P25-P75) | pCR rate | P-value | |
| Gender | Male | 63 | 35 | 35.71% | 1 |
| Female | 18 | 10 | 35.71% | ||
| Age (yr) | ≤ 60 | 62 | 34 | 35.42% | 0.901 |
| > 60 | 19 | 11 | 36.67% | ||
| BMI (kg/cm2) | < 25 | 49 | 34 | 40.96% | 0.202 |
| ≥ 25 | 23 | 9 | 28.13% | ||
| Hemoglobin (g/L) | ≤ 125 | 23 | 13 | 36.11% | 0.905 |
| > 125 | 41 | 22 | 34.92% | ||
| NLR | > 3 | 9 | 6 | 40.00% | 0.683 |
| ≤ 3 | 55 | 29 | 34.52% | ||
| PLT (×109/L) | 246.5 (214.25-289.75) | 239 (197-269) | 0.22 | ||
| ApoA1 (g/L) | 1.26 (1.15-1.44) | 1.3 (1.15-1.55) | 0.453 | ||
| ApoB (g/L) | 1 (0.81-1.24) | 0.97 (0.81-1.17) | 0.725 | ||
| The interval | 51.5 (43-58.75) | 54 (50-62) | 0.116 | ||
| CEA (ng/mL) | > 5 | 40 | 16 | 28.57% | 0.107 |
| ≤ 5 | 24 | 19 | 44.19% | ||
| Differentiation | Moderate-poor | 63 | 30 | 32.26% | 0.311 |
| Well | 13 | 10 | 43.48% | ||
| DTAV (cm) | < 5 | 33 | 25 | 43.10% | 0.11 |
| ≥ 5 | 48 | 20 | 29.41% | ||
| TL (cm) | > 3 | 64 | 27 | 29.67% | 0.008 |
| ≤ 3 | 13 | 17 | 56.67% | ||
| TCE | < 50% | 8 | 4 | 33.33% | 0.944 |
| ≥ 50% | 65 | 34 | 34.34% | ||
| cT | 2 | 0 | 2 | 100.00% | 0.061 |
| 3 | 58 | 35 | 37.63% | ||
| 4 | 18 | 5 | 21.74% | ||
| cN | + | 62 | 36 | 36.73% | 0.946 |
| - | 16 | 9 | 36.00% | ||
| MRF | - | 49 | 39 | 44.32% | 0.002 |
| + | 32 | 6 | 15.79% | ||
Platelet, apolipoprotein A-1, apolipoprotein B, and the interval were calculated as metrological data, and others are counting data. pCR: Complete pathological response; NLR: Neutrophil-lymphocyte ratio; DTAV: Distance of tumor from the anal verge; TL: Tumor length; TCE: Tumor circumferential extent; PLT: Platelet; ApoA1: Apolipoprotein A-1; ApoB: Apolipoprotein B; MRF: Mesorectal fascia; CEA: Carcinoembryonic antigen.