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. Author manuscript; available in PMC: 2019 Jan 11.
Published in final edited form as: Nat Rev Cardiol. 2017 Apr 24;14(8):484–491. doi: 10.1038/nrcardio.2017.57

Figure 3 |. Lineage tracing of resident cardiac fibroblasts.

Figure 3 |

Hearts from adult Tcf21mCrem mice containing a Cre-dependent ROSA26TdT indicator that was induced with tamoxifen perinatally. Tissue-resident fibroblasts are labelled red. Mice were subjected to either a | a sham surgical procedure (no injury) or b | 6 weeks of a thoracic aortic constriction surgical procedure before harvesting. The images show that Tcf21-lineage tissue-resident fibroblasts are uniformly distributed throughout the heart and that they expand with pressure-overload stimulation.