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. 2019 Jan 10;17:18. doi: 10.1186/s12967-019-1774-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — PIAS3 reciprocally regulates the Th17/Treg cell imbalance. Spleen tissues were isolated from mice in each group at 10 weeks after curdlan injection. a Tissues were stained with specific Abs against CD4 (red), CD25 (blue), IL-17 (green), FOXP3 (green), p-STAT3 y705 (green), p-STAT3 s727 (green), p-STAT5 (green), and PIAS3 (green). Positive cells are shown in the bar graphs. b, c Splenocytes were stained with Abs against CD4–PerCP, IL-17–FITC, IFNγ-PE, CD25-APC, FOXP3–FITC, and PIAS3-APC to determine the presence of Th17, Tregs and PIAS3 expression on CD4⁺ T cells. Data are expressed as the mean ± SEM of three independent experiments (*P < 0.05, ***P < 0.001)