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. 2019 Jan 11;20:9. doi: 10.1186/s12881-018-0739-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Significance of interactions between the IGF pathway genes and environmental factors. Negative natural log transformed p-values from the twin model, the linear mixed model and the PBI test were compared with unadjusted significance level (ɑ = 0.05) and Bonferroni-adjusted level (ɑ_adj = 0.006). Genetic (IGF-1, IGFALS) and environmental (physical activities, daycare attendance, sleep duration) main effects were evaluated by the twin and linear mixed models. All methods estimated significance of gene-environment interaction effects. Any effect with significance per unadjusted level (p-value < 0.05) is labeled for the involved IGF-1 or IGFALS SNP. LMM = linear mixed model; PBI = partition based score I test