Table 2.
Baseline characteristics of treated limbs and transplants
| Total, n = 103 | Responders, n = 58 | Non-responders, n = 45 | P value | |
|---|---|---|---|---|
| Rutherford class, n (%) | ||||
| IV | 12 (11.6%) | 5 (8.6%) | 7 (15.6%) | 0.277 |
| V | 91 (88.4%) | 53 (91.4%) | 38 (84.4%) | 0.277 |
| Gangrene, n (%) | ||||
| Yes | 46 (44.7%) | 25 (43.1%) | 21 (46.7%) | 0.718 |
| No | 57 (55.3%) | 33 (56.9%) | 24 (53.3%) | 0.718 |
| ABI* (median [IQR]) | 0.485 (0.370–0.640) | 0.515 (0.410–0.695) | 0.430 (0.280–0.540) | 0.011 |
| TcPO2 (mmHg) (median [IQR]) | 17 (6–28) | 24 (14–30) | 9 (4–19) | < 0.001 |
| Highest level of arterial occlusion | ||||
| Above the knee or elbow, n (%) | 62 (60.2%) | 28 (46.6%) | 34 (77.8%) | 0.001 |
| Common or external iliac artery, n (%) | 4 (3.9%) | 1 (1.7%) | 3 (6.7%) | 0.198 |
| Common femoral artery or axillary artery, n (%) | 5 (4.8%) | 4 (6.9%) | 1 (2.2%) | 0.383 |
| Superficial femoral artery or brachial artery, n (%) | 36 (35.0%) | 15 (25.9%) | 21 (46.7%) | 0.037 |
| Popliteal artery, n (%) | 17 (16.5%) | 7 (12.1%) | 10 (22.2%) | 0.169 |
| Below the knee or elbow, n (%) | 41 (39.8%) | 31 (53.4%) | 10 (22.2%) | 0.001 |
| Artery in the calf or forearm, n (%) | 28 (27.2%) | 23 (39.7%) | 5 (11.1%) | 0.001 |
| Artery below the ankle or wrist, n (%) | 13 (12.6%) | 8(13.7%) | 5 (11.1%) | 0.684 |
| Type of transplantation | ||||
| Purified for CD34+ cells, n (%) | 52 (50.5%) | 30 (51.7%) | 22 (48.9%) | 0.775 |
| Not purified, n (%) | 51 (49.5%) | 28 (48.3%) | 23 (51.1%) | 0.775 |
| Total transplanted CD34+ cells (million/L) (median [IQR]) | 43.0 (26.0–84.0) | 51.5 (26.0–103.0) | 40.0 (26.0–68.0) | 0.114 |
| Cell viability (median [IQR]) | 98.4% (97.7%–98.6%) | 98.3% (97.5%–98.6%) | 98.4% (98.2%–98.6%) | 0.212 |
*ABIs of 99 patients with lower limbs treated were included in this analysis, while the other 4 patients with upper limbs treated were excluded
IQR, interquartile range; ABI, ankle-brachial index; TcPO2: transcutaneous pressure of oxygen; CD, cluster of differentiation