Table 3.
Univariate and multivariate logistic regression analysis of prognostic factors
| Candidate variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR(95% CI) | P value | OR (95% CI) | P value | |
| Age ≥ 50 years | 0.276 (0.118–0.647) | 0.003 | 0.201 (0.068–0.595) | 0.004 |
| Body mass index (kg/m2) | 1.032 (0.909–1.172) | 0.627 | ||
| Diabetes mellitus | 0.286 (0.053–1.547) | 0.146 | ||
| Hypertension | 0.286 (0.053–1.547) | 0.146 | ||
| Hyperlipidemia | 3.259 (0.351–30.22) | 0.298 | ||
| Smoker | 2.357 (0.831–6.684) | 0.107 | ||
| CRP > 3 mg/L | 0.287 (0.117–0.702) | 0.006 | ||
| Fibrinogen > 4 g/L | 0.172 (0.064–0.459) | < 0.001 | 0.176 (0.055–0.563) | 0.003 |
| Etiology = ASO | 0.296 (0.072–1.218) | 0.092 | ||
| Rutherford class = IV | 0.512 (0.151–1.736) | 0.283 | ||
| Gangrene | 0.866 (0.396–1.894) | 0.718 | ||
| Arterial occlusion above the knee or elbow* | 0.249 (0.104–0.595) | 0.002 | 0.232 (0.077–0.703) | 0.010 |
| ABI** | 8.345 (1.301–53.54) | 0.025 | ||
| TcPO2 (mmHg) | 1.069 (1.030–1.109) | < 0.001 | 1.062 (1.017–1.110) | 0.006 |
| Using purified CD34+ cells | 0.913 (0.425–1.961) | 0.816 | ||
| Log (total transplanted CD34+ cell counts)*** | 2.274 (0.850–6.079) | 0.102 | 3.506 (1.021–12.039) | 0.046 |
*Defined as the highest occlusion level located at common iliac artery, external iliac artery, common femoral artery, superficial femoral artery, popliteal artery, axillary artery, or brachial artery
**ABIs of 99 patients with lower limbs treated were included in this analysis, while the other 4 patients with upper limb lesions were excluded
*** Base-10 logarithm of total transplanted CD34+ cell counts
OR, odds ratio; CI, confidential interval; CRP, C-reaction protein; ASO, atherosclerosis obliterans; ABI, ankle-brachial index; TcPO2: transcutaneous pressure of oxygen; CD, cluster of differentiation