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. 2019 Jan 11;16:4. doi: 10.1186/s12986-018-0327-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Fluorochrome-labelled sections and microradiographs of the metaphysis of the tibiae. Fluorochrome-labelled sections (first row) and microradiographs (second row) in the NON-OVX (a), OVX (b) and baicalein-treated groups in ascending doses (c-e) showed delayed healing, with a large osteotomy gap in the OVX group, whereas in the baicalein-treated groups, the osteotomy gap was smaller and the callus more compact and denser, primarily at the edges. The red box shows an exemplary bridged callus area on day 26. In the NON-OVX group, bone healing at the advanced stage showed a compact dense callus around the gap (NON-OVX n = 9, OVX n = 9, C1 n = 7, C2 n = 7, C3 n = 10)