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. 2019 Jan 11;10:12. doi: 10.1186/s13287-018-1115-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Exosomal miR-126 regulated RAF/ERK signaling through targeting SPRED-1. a Western blot analysis showed that EPC-Exos reduced SPRED-1 levels but induced phosphorylation of ERK and RAF. b Quantitative analysis of SPRED-1, p-RAF, and p-ERK. **P < 0.01, ^#P < 0.001 vs PBS. Exo exosomes secreted by endothelial progenitor cells, PBS phosphate-buffered saline