Table 2.

miRNAs, target genes and their functions in GC apoptosis and follicular atresia

miRNA	Species	Target	Function	Reference
let-7 g	porcine	MAP3K1	promotes GC apoptosis	[61]
let-7 g	porcine	TGFBR1	promotes GC apoptosis	[58]
miR-10b	goat	BDNF	suppresses GC proliferation	[118]
miR-15a	human	unknown	promotes release of progesterone and testosterone	[91]
miR-21	mouse	unknown	inhibits apoptosis, increases ovulation rate	[119]
miR-22	mouse	Sirt1	inhibits GC apoptosis	[120]
miR-23a	human	SMAD5	promotes GC apoptosis	[78, 121]
miR-26b	porcine	ATM	promotes GC apoptosis	[42]
miR-26b	porcine	SMAD4	promotes GC apoptosis	[64]
miR-26b	porcine	HAS2	promotes GC apoptosis	[122]
miR-27a	human	SMAD5	promotes GC apoptosis	[78]
miR-34a	porcine	INHBB	promotes GC apoptosis	[123]
miR-34c	porcine	unknown	proapoptotic and antiproliferative factor	[124]
miR-92a	porcine	SMAD7	inhibits GC apoptosis	[65]
miR-93	human	CDKN1A	promotes GC proliferation	[125]
miR-106a	human	apoptosis signal-regulating kinase 1 (ASK1)	reduces GC viability and promotes apoptosis	[111]
miR-125a-5p	mouse	Stat3	promotes GC apoptosis	[126]
miR-126*	porcine	FSHR	promotes AR-induced GC apoptosis	[127]
miR-146a	human	IRAK1/TRAF6	promotes GC apoptosis	[128]
miR-181b	porcine	SMAD7	inhibits GC apoptosis	[67]
miR-182	rat	Smad7	inhibits GC apoptosis	[66]
miR-224	mouse	Smad4	inhibits GC proliferation and E2 release	[63]
miR-320	mouse	E2f1/Sf-1	inhibits E2 synthesis and GC proliferation	[129]
miR-378-3p	bovine	PGR	inhibits GC differentiation	[130]
miR-378	porcine	CYP19A1	decreases E2 production	[88]
miR-383	mouse	Rbms1	enhances E2 release from GCs	[131]
miR-503/322/351 Cluster	mouse	Autophagy/Mitophagy-Associated Genes	reduces of mitochondrial activity in GC	[132]
miR-764-3p	mouse	Sf-1	decreases steroidogenesis	[89]
miR-1275	porcine	LRH-1	represses E2 synthesis	[50]