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. 2019 Jan 4;25:98–106. doi: 10.12659/MSM.911818

Figure 3.

Figure 3

Tripartite motif-containing protein 11 (TRIM11) inhibited prostate cancer growth and was downregulated by miR-5193 in PC3 and DU143 prostate cancer cells in vitro. (A) MTT assays of PC3 and DU143 cells with tripartite motif-containing protein 11 (TRIM11) gene silencing shows the effect of TRIM11 on increasing cell proliferation when compared with the negative control. * P<0.05. (B) The microRNA-5193 (miRNA-5193) binding sites in the 3′UTR of TRIM11 was predicted by TargetScan analysis. (C) The level of miR-5193 in the miR-5193 mimic group was significantly increased compared with the negative control group. * P<0.01. (D) TRIM11 expression was downregulated by overexpression of miR-5193 in both PC3 and DU143 prostate cancer cell lines in vitro.