Table 1.
Basic Characteristics of the Included Studies.
| Study ID | Sex (M/F) | AVG age | N (E/C) | TNM stages | EST (m) | KPS score | Therapy of CHIs+radiotherapy group | Therapy of radiotherapy group | Treatment (days) | Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|
| Yang YM 2013 | 38/22 | 48 | 30/30 | I–III | ≥3 | >60 | AD 100 ml+ DT = 66Gy | DT = 66Gy | 30d | ① ② |
| Fang H 2011 | 38/22 | 48 | 30/30 | I–III | ≥3 | >60 | AD 100 ml+ DT = 66Gy | DT = 66Gy | 30d | ① ② |
| Zeng QB 2006 | NR | NR | 72/72 | NR | NR | NR | AD 100 ml+ DT = 60–70Gy | DT = 60–70Gy | 15d × (2–3) | ① ④ |
| Mao HY 2016 | 80/30 | 65 | 55/55 | NR | ≥3 | ≥60 | AD 100 ml+ DT = 50–66Gy | DT = 50–66Gy | 30d | ① ③ |
| Zhao KY 2010 | 54/16 | 57 | 40/30 | II–IV | ≥5 | >60 | AD 50 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ② |
| Guo YC 2014 | 56/40 | 57 ± 5 | 50/46 | II–IV | ≥6 | ≥70 | AD 50 ml+ DT = 60–66Gy | DT = 60–66Gy | 7d × (6–7) | ① ③ |
| Li MJ 2014 | 43/17 | 58 | 30/30 | II–IV | >6 | ≥60 | AD 50 ml+ DT = 60Gy | DT = 60Gy | 5d × 4 | ① ③ |
| Lu K 2006 | 56/29 | 56 | 43/42 | II–III | NR | ≥70 | AD 60 ml+ DT = 60–70Gy | DT = 60–70Gy | 21d | ① ③ |
| Hu LM 2010 | 42/26 | 58.4 | 34/34 | NR | NR | ≥70 | AD 50 ml+ DT = 64–70Gy | DT = 64–70Gy | 7d × (6–7) | ③ ④ |
| Bai LK 2014 | 33/16 | 75.4 | 25/24 | NR | NR | >60 | AD 50 ml+ DT = 50–70 Gy | DT = 50–70 Gy | 7d × (4–7) | ③ ④ |
| Zhao X 2015 | 40/32 | NR | 36/36 | NR | ≥6 | ≥70 | AD 50 ml+ DT = 64Gy | DT = 64Gy | 7d × (6–7) | ③ ④ |
| Han JW 2008 | NR | 71.5 | 48/47 | II–IV | NR | ≥70 | AD 50 ml+ DT = 65–70Gy | DT = 65–70Gy | 7d × (6–7) | ① ③ |
| Xing HJ 2011 | 46/34 | 70.5 | 40/40 | NR | >3 | ≥70 | AD50 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ② ③ ④ |
| Wu YH 2001 | NR | NR | 48/48 | NR | NR | >60 | AD 30–50 ml+ DT = 68–70Gy | DT = 68–70Gy | 7d × (6–7) | ① ③ ④ |
| Liu XP 2006 | 36/12 | 75 | 24/24 | NR | NR | ≥60 | AD 60 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ② ③ |
| Jiang SN 2010 | 36/14 | 64.5 | 26/24 | NR | NR | 70–90 | DC 0.5–1.0 mg+ DT = 60Gy | DT = 60Gy | 7d × 6 | ① |
| Zhou M 2009 | 44/19 | 51.5 | 32/31 | NR | NR | ≥70 | SM 50 ml+ DT = 60Gy | DT = 60Gy | 10d × 3 | ① ③ ④ |
| Zhu GJ 2013 | NR | NR | 30/30 | NR | NR | 60–80 | SQFZ 250 ml+ DT = 64Gy | DT = 64Gy | 28d | ③ ④ |
| Cai P 2006 | 98/28 | NR | 53/73 | NR | NR | >60 | CKS 20 ml+ DT = 66–74Gy | DT = 66–74Gy | 20d | ③ ④ |
| Yan L 2015 | 45/35 | 55 | 40/40 | I–IV | NR | ≥70 | CKS 20 ml+ DT = 60–66Gy | DT = 60–66Gy | 14d | ② ③ |
| Sun TZ 2009 | 53/17 | 55.5 | 35/35 | NR | NR | >60 | CKS 20 ml+ DT = 60–70Gy | DT = 60–70Gy | 21d | ③ ④ |
| Huang CH2016 | 49/31 | 70–80 | 40/40 | NR | NR | ≥70 | CKS 15–20 ml+DT = 60–66Gy | DT = 60–66Gy | 7d × (6–7) | ③ ④ |
| Ao JF 2006 | 21/11 | 56.8 | 18/14 | III–IV | NR | ≥60 | CKS 20 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (4–6) | ① ③ |
| Chen XY 2006 | 54/13 | 55 | 33/35 | NR | NR | ≥60 | CKS20–40 ml+DT = 66.6–67Gy | DT = 66.6–67Gy | 10d × (3–4) | ① ② ③ ④ |
| Sheng ZJ 2009 | 67/61 | 72.2 | 66/62 | III | NR | NR | CKS 20 ml+ DT = 60Gy | DT = 60Gy | (14–35)d | ② ③ |
| Ding JQ 2011 | 23/25 | 55.2 | 24/24 | NR | NR | ≥70 | CKS 20 ml+ DT = 65.4–67Gy | DT = 65.4–67Gy | 20d | ② ③ ④ |
| Li Z 2012 | 48/19 | 63 | 35/32 | II–III | >3 | >60 | CKS 15 ml+ DT = 60–66Gy | DT = 60–66Gy | 14d × (2–3) | ① ② ③ |
| Luo M 2013 | NR | NR | 26/23 | NR | >3 | >70 | CKS 25 ml+ DT = 50–66Gy | DT = 50–66Gy | 7d × (5–7) | ③ |
| Liu FX 2009 | 66/34 | 53.2 | 50/50 | NR | NR | ≥60 | CKS 20 ml+ DT = 54–66Gy | DT = 54–66Gy | (14–21)d | ② |
| Zhou DA 2002 | 116/44 | 61.9 | 80/80 | NR | NR | ≥70 | HCS 20 mL+ DT = 60–70Gy | DT = 60–70Gy | 28d | ① |
| Tian SP 2013 | 12/10 | 72–89 | 10/12 | NR | >6 | >70 | CHS 20 mL+ DT = 60Gy | DT = 60Gy | 7d × 6 | ③ |
| Zhang FT 2001 | 32/28 | 55 | 30/30 | NR | >3 | >70 | CHS 40 mL+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ④ |
| Wang ZM 2010 | 34/22 | 68 | 28/28 | NR | NR | ≥70 | CHS20–30 mL+DT = 40–50Gy | DT = 40–50Gy | (21–28)d | ① ② ③ |
| He WX 2007 | 38/22 | 48 | 30/30 | I–III | ≥3 | >60 | AP 250 ml+ DT = 66Gy | DT = 66Gy | 2ld | ① ② |
| Fan T 2012 | NR | NR | 60/60 | NR | NR | ≥60 | AI 30 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ③ |
| An SH 2008 | 35/5 | 71 | 20/20 | NR | NR | NR | KA 40 ml+ DT = 60–64Gy | DT = 60–64Gy | 7d × (6–7) | ② |
| Zhao DL 2006 | 38/22 | 48 | 30/30 | I–III | NR | NR | KA 60 ml+ DT = 66Gy | DT = 66Gy | 7d × (6–7) | ① ② |
| Wang WH2014 | 49/29 | 55.9 | 39/39 | III–IV | ≥3 | ≥70 | KA 60 ml+ DT = 50–70Gy | DT = 50–70Gy | 28d × 2 | ① ③ |
| Mu Y 2012 | 32/18 | 54 | 25/25 | NR | NR | ≥70 | KA 60 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × 6 | ① ② |
| Zhang HF 2014 | 39/11 | 61 | 25/25 | NR | NR | NR | KA 50 ml+ DT = 60–66Gy | DT = 60–66Gy | 7d × (6–7) | ① ③ |
| Wu ZP 2013 | 56/31 | 72.3 | 43/44 | NR | >3 | >60 | KA 60 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ② ③ ④ |
| Ren MZ 2013 | 39/15 | NR | 28/26 | NR | NR | ≥60 | KA 40–60 ml+ DT = 60Gy | DT = 60Gy | 30d × 2 | ① ③ |
| Ding H2013 | 59/21 | 58.5 | 40/40 | NR | NR | ≥80 | EL 200 mg+ DT = 50–60Gy | DT = 50–60Gy | 7d × (6–7) | ① ③ |
| Zhu XG 2016 | 51/41 | 67.6 | 50/42 | II–III | NR | NR | EL 600 mg+ DT = 50–60Gy | DT = 50–60Gy | 30d × 2 | ① ③ ④ |
| Wu J 2011 | 37/23 | 56 | 30/30 | NR | >3 | >70 | LE lmg+ DT≥ 45Gy | DT≥45Gy | 7d × 6 | ① ② ③ |
| Feng SJ 2015 | 35/25 | 65.5 | 30/30 | NR | NR | NR | JOE 30 ml+ DT = 60Gy | DT = 60Gy | 21d × 3 | ① ③ |
| Li DZ 2011 | 37/19 | 53 | 28/28 | NR | NR | ≥70 | JOE 30 ml+ DT = 50–60Gy | DT = 50–60Gy | 21d | ① ④ |
| Li Q 2013 | 36/14 | 62 | 25/25 | NR | >12 | ≥70 | JOE 30 ml+ DT = 60Gy | DT = 60Gy | 7d × 6 | ① ④ |
| Jia YS 2008 | 116/32 | 55.6 | 76/72 | NR | NR | ≥70 | JOE 30–50 ml+ DT = 60–68Gy | DT = 60–68Gy | 30d | ② ③ ④ |
| Chen SD 2007 | 65/27 | NR | 44/48 | NR | NR | ≥70 | JOE 10–20 ml+ DT = 64–70Gy | DT = 64–70Gy | 7d × (6–7) | ③ |
| Jiang XC 2009 | 41/28 | 55.6 | 35/34 | NR | NR | ≥70 | JOE 30 ml+ DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ③ |
| Kong XM 2004 | 47/13 | 55.6 | 30/30 | NR | NR | >60 | JOE 30 ml+ DT = 60–70Gy | DT = 60–70Gy | 21d × 2 | ① ③ ④ |
| Liu XX 2010 | 39/17 | 61 | 28/28 | NR | NR | 60–80 | JOE 30 ml+ DT = 60–70Gy | DT = 60–70Gy | 21d × 2 | ① ③ |
| He LJ 2010 | 63/7 | 63 | 35/35 | NR | NR | ≥60 | JOE 30 ml + DT = 60–70Gy | DT = 60–70Gy | 7d × (6–7) | ① ③ |
| Qi JH 2015 | 68/42 | 61.8 | 61/49 | NR | NR | ≥60 | JOE 20–30 ml+ DT = 60–66Gy | DT = 60–66Gy | 7d × (6–7) | ① ② |
M, male; F, female; E, experimental group; C, control group; NR, not reported; EST, expected survival time; m, month; d, day; c, cycle; ①, clinical effectiveness rate; ②, performance status, ③, ADRs; ④, survival rate; AD, Aidi injection; AI, Astragalus injection; AP, Astragalus polysaccharide injection; CKS, Compound kushen injection; DC, Disodium cantharidinate and vitamin B6 injection; EL, Elemene injection; HCS, Huachansu injection; JOE, Javanica oil emulsion injection; KA, Kangai injection; LE, Lentinan injection; SM, Shenmai injection; SQFZ, Shenqifuzheng injection; DT, radiation absorbed dose.