Skip to main content
. Author manuscript; available in PMC: 2019 Jan 11.
Published in final edited form as: Oncogene. 2010 May 3;29(25):3650–3664. doi: 10.1038/onc.2010.129

Figure 6.

Figure 6

(a) Illumina array analysis of gene expression in untreated HBEC, and spontaneous clones from control HBEC emerging from soft agar, as well as clones exposed to CSC and then expanded with or without additional tobacco smoke exposure. Gene expression profiles in untreated controls as well as spontaneous control clones were remarkably similar. Interestingly, array analysis revealed that gene expression profiles in clones derived from CSC-treated HBEC that were subsequently expanded without further CSC exposure were markedly altered; additional CSC exposure further modulated gene expression in HBEC, reflecting acute effects of CSC. (b) Ingenuity analysis of Illumina gene expression arrays revealing major pathways modulated in CSC-derived soft-agar clones expanded in the absence (CSC−) or presence (CSC+) of CSC.