Figure 6.

Landscape of somatically mutated genes that are promising for being prognostic (n = 22, FDR < 0.4) in the TCGA stage III/IV cohort following OS-original diagnosis and OS-time from specimen collection analyses. Only tumors with mutations in at least one of the 22 genes are shown in the center of the matrix (190 out of a total of 356). Mutated genes are shown as a binary outcome (presence/absence) for each sample and are color-coded according to the presence/absence of mutations as identified by DNA-seq (dark gray or light gray) and RNA-seq analysis [filled circles (∙) or open circles (°)]. Total number of somatic mutations (# Mutations, top), vital status, age at specimen collection (≤ 65, >65 years old), OS follow-up (in years), AJCC stage at specimen procurement, molecular classification [BRAF hotspot, RAS hotspot, NF1 mutations (□ indicates nonsense mutation), triple wild-type (TWT)], RNA-seq classification, mutation spectra (left panel), and mutated gene frequency (right panel) for each of the 14 mutated genes (left) are shown for each sample.