. Author manuscript; available in PMC: 2019 Jan 11.

Published in final edited form as: Adv Anat Pathol. 2009 Nov;16(6):392–404. doi: 10.1097/PAP.0b013e3181bb6bc2

TABLE 1.

PDC Immunophenotype. Antigens Labeled With (F) or (P) are Particularly Helpful for PDC Indentification on Frozen or Paraffin Sections, Respectively.

CD designation
Positive	CD4, CD11a, CD31, CD32, CD36 (F), CD40, CD43, CD44, CD45RA, CD45RB, CD49e,
	CD62L^*,CD68 (P), CD71, CD74, CD123 (P), CD128, CD162
Negative	CD1, CD2^†, CD3, CD5^†, CD7^†, CD8, CD10, CD11b, CD11c^‡, CD13^‡, CD14, CD15^§, CD16,
	CD19, CD20, CD21, CD23, CD25, CD27, CD28, CD30, CD33^‡, CD34, CD38, CD45RO,
	CD56^†, CD57, CD64, CD65, CD80, CD83, CD86, CD94, CD95, CD103, CD117, CD125,
	CD138, CDw150, CD161
Chemokine receptors
Positive	CCR2, CCR5, CCR7^‡, CXCR3, CXCR4, Chemerin Receptor
Negative	CCR1, CCR3, CCR4, CCR6, CXCR1, CXCR2, CXCR5
Toll-like and pattern recognition receptors
Positive	TLR1 (CD281)^∥, TLR6 (CD286)^∥, TLR7 (CD287), TLR9 (CD289), TLR10 (CD290)^∥, BDCA-2
	(CD303)(P)
Negative	TLR2 (CD282), TLR3 (CD283), TLR4 (CD284), TLR5 (CD285), TLR8 (CD288), Mannose
	receptor (CD206), DC-SIGN (CD209)
Miscellaneous
Positive	BCL11a, BDCA-4 (Neuropilin-1/CD304), CD2AP (P), CLA/HECA-452(P), E-cadherin^†,
	Granzyme B(P), HLA-ABC, HLA-DP, HLA-DQ, HLA-DR, MxA, TCL1 (P)
Negative	DC-LAMP (CD208), Elastase, FOXP3, Langerin (CD207), LAT, Lysozyme, MUM1/IRF4,
	Myelopero xidase, Perforin, S-100, slg and clg, T-bet, T-cell receptor αβ and γ^§, TdT, TIA-1,
	ZAP70

Membranous expression on circulating PDCs and cytoplasmic on tissue PDCs.

^†

Positivity reported in a subset of circulating PDCs

^‡

Expression induced upon in vitro differentiation or activation.

^§

Positivity after neuraminidase digestion.

^∥

Low expression

BDCA indicates blood dendritic cell antigen; CLA, cutaneous lymphocyte-associated antigen; MxA, myxovirus A; PDC, plasmacytoid dendritic cell; TCL, T-cell leukemia/lymphoma; TdT, terminal deoxynucleotidyl transferase; TLR, Toll-like receptor.