TABLE 3.
Clinical and Immunophenotypic Features of BPDCN Cases Reviewed at the National Cancer Institute, Bethesda, MD
| Presenting With Cutaneous Involvement | Lacking Cutaneous Involvement at Presentation | |
|---|---|---|
| Number of patients | 46 (84% of total) | 9 (16% of total) |
| Age (y): median, range | 67; 4-87 | 68; 10-84 |
| Male/female, ratio | 34/12; 2.8: 1 | 6/3; 2:1 |
| Prior or concomitant myeloid neoplasia | 4/46 (9%) | 1/9 (11%) |
| Immunophenotype | ||
| CD4 | 39/39 (100%) | 8/8 (100%) |
| CD56 | 44/45 (98%) | 9/9 (100%) |
| CD123 | 32/32 (100%) | 7/7 (100%) |
| TdT | 22/41 (54%) | 6/7 (86%) |
| S-100 | 6/18 (33%) | 1/5 (20%) |
| CD3 | 0/38 (0%) | 0/9 (0%) |
| CD34 | 0/17 (0%) | 0/4 (0%) |
| CD117 | 0/16 (0%) | 0/4 (0%) |
BPDCN indicates blastic plasmacytoid dendritic cell neoplasm; TdT, terminal deoxynucleotidyl transferase.