Figure 2.

Expansion of CCR9⁺ CD4⁺ T cells in Il2^−/− mice. Numeration (A) and percentages (B) of CCR9⁺ and CCR9⁻ CD44^hi CD4⁺ T cells in Il2^−/− and WT mice determined by FACS analysis. (MLN) mesenteric lymph nodes; (PP) Peyer's Patches; (SI IEL) intraepithelial lymphocytes of the small intestine; (SI LPL) lamina propria lymphocytes of the small intestine; (LI IEL) intraepithelial lymphocytes of the large intestine; (LI LPL) lamina propria lymphocytes. (C) Percentages of FoxP3⁺ CD4⁺ TCRb⁺ T regulatory (Treg) cells in the spleen and MLN and (D) percentages of CXCR5⁺ PD1⁺ FoxP3⁻ CD4⁺ TCRb⁺ T follicular helper (Tfh) cells in the PP and MLN of Il2^−/− and WT mice. Data shown as mean ± SD, where n = 3-15 female mice 7-9 weeks of age. Statistical significance was analyzed by students T-test.