Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 4;9:2899. doi: 10.3389/fimmu.2018.02899

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Cosorich, McGuire, Warren, Danta and King.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CCR9⁺ Tfh cells express increased amounts of IL-21 and IL-17. Percentages of cytokine expressing CCR9⁺ and CCR9⁻, CXCR5⁺ PD1⁺ CD4⁺ T follicular helper (Tfh) cells in the Peyers patches (PP) and mesenteric lymph nodes (MLN) of Il2^−/− and WT mice. Interleukin (IL) 17 and 21 were detected ex vivo by intracellualr immunostaining and FACs analyses. IL-21 containing CCR9⁺ and CCR9⁻ Th cells in the (A) PP and (B) MLN. IL-17 containing CCR9⁺ and CCR9⁻ Th cells in the (C) PP and (D) MLN. Data are shown as mean ± SD from 3 experiments, where n = 5 female mice of 9–12 weeks of age. Statistical significance was assessed by 2-way ANOVA using Bonferroni's multiple comparisons test.