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. 2018 Dec 11;91(24):1092–1104. doi: 10.1212/WNL.0000000000006642

Figure 3. Brain MRI/CT findings of colony-stimulating factor-1 receptor (CSF1R)-related leukoencephalopathy.

Figure 3

(A–D, F, H) A 44-year-old woman with CSF1R p.G589R. (E) A 27-year-old woman with CSF1R c.2442+5 G > A. (G) A 31-year-old woman with CSF1R p.A652P. All of these patients have been reported previously.41 (A, B), Bilateral diffuse white matter hyperintensity with pyramidal tract involvement (arrows in A), cortical atrophy, and enlarged lateral ventricles on fluid-attenuated inversion recovery MRI. (C) Longitudinal pyramidal tract involvement (arrows) on coronal T2-weighted image. (D) Thinning of the corpus callosum with hyperintensity on sagittal fluid-attenuated inversion recovery image. (E) Hyperintensity lesions in the subcortical white matter on diffusion-weighted image. (F) Small calcifications located bilaterally near the anterior horns of the lateral ventricles on brain CT image. (G) Calcifications in parietal subcortical white matter. (H) Stepping stone appearance of calcifications (arrows) in the frontal pericallosal region on sagittal CT image.