Table 2.
Exacerbation rates by phenotype
| Phenotype | No. of events | Time at risk (1,000 person-years) | Crude rate/1,000 person-years (95% CI) | Minimally adjusted | Adjusted rates |
|---|---|---|---|---|---|
|
| |||||
| Benign asthma | 3,431 | 30.867 | 106.8 (101.2–112.3) | 116.2 (110.1–122.3) | 143.2 (135.6–150.8) |
| Atopic asthma | 68,143 | 239.664 | 283.2 (278.6–287.7) | 286.9 (282.3–291.5) | 322.1 (316.6–327.5) |
| Obese non-eosinophilic | 19,263 | 42.471 | 469.0 (451.7–486.2) | 454.9 (438.0–471.7) | 439.3 (422.5–456.2) |
| NOS no medication | 10,495 | 70.978 | 143.8 (139.3–148.3) | 148.1 (143.4–152.7) | 174.6 (169.0–180.2) |
| NOS with reliever Tx | 9,529 | 48.238 | 200.7 (193.2–208.1) | 208.6 (200.9–216.3) | 240.0 (231.1–249.0) |
| NOS with maintenance Tx | 1,47,527 | 387.403 | 388.2 (383.5–392.9) | 389.4 (384.6–394.1) | 414.0 (408.6–419.3) |
Notes: Minimally adjusted: adjusted for age and sex. Adjusted rates: adjusted for age, sex, smoking, BMI, IMD, anxiety, depression, COPD, GORD, vaccination status and asthma treatment step. Unless otherwise indicated, values are given as rates (95% CI).
Abbreviations: BMI, body mass index; GORD, gastro-oesophageal reflux disease; IMD, index of multiple deprivation; NOS, not otherwise specified; Tx, treatment.