Table 4. Management of last intake of non-vitamin K antagonist oral anticoagulants (NOACs) before elective procedures taking into consideration ?bleeding risk and renal function (adapted from [38]).

	Dabigatran		Apixaban – Edoxaban – Rivaroxaban
Creatinine clearance	Low bleeding risk	High bleeding risk	Low bleeding risk	High bleeding risk
≥ 80 mL/min	≥ 24 h	≥ 48 h	≥ 24 h	≥ 48 h
50–80 mL/min	≥ 36 h	≥ 72 h	≥ 24 h	≥ 48 h
30–50 mL/min	≥ 48 h	≥ 96 h	≥ 24 h	≥ 48 h
15–30 mL/min	Not indicated	Not indicated	≥ 36 h	≥ 48 h
<15 ml/min	No approved NOAC indication