Table 1.
Data for individual macaques in MRI study [AU: Provide table in normal black font without colors]
| Pre- Infarction |
Post-Infarction Baseline MRI | MRI 4 weeks after treatment | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Animal # |
Sex | Age | Weight, kg |
Infarct size (histology), % of LV |
Graft size, % of infarct |
Graft cell number (millions) |
LVEF by Echo, % |
LVEDV, ml |
LVESV, ml |
LVEF, % |
Infarcted LVTh, % |
Infarct size, % of LV |
LVEDV, ml |
LVESV, ml |
LVEF, % |
Infarcted LVTh, % |
Infarct size, % of LV |
| Control | |||||||||||||||||
| P14 | M | 6y 10mo | 12.6 | 29.2 | NA | NA | 68 | 18.0 | 10.2 | 43.9 | 0 | 19 | 20.7 | 11.4 | 44.8 | 0 | 18 |
| P15 | F | 9y 7mo | 11.7 | 22.2 | NA | NA | 74 | 19.0 | 11.6 | 39.1 | 0 | NA | 23.6 | 13.4 | 43.1 | 0 | NA |
| P18 | F | 10y 9mo | 11.4 | 18.1 | NA | NA | 67 | 16.1 | 10.7 | 33.4 | 0 | 15 | 18.3 | 11.9 | 34.7 | 0 | 13 |
| P20 | F | 6y 0mo | 10.6 | 25.0 | NA | NA | 70 | 15.5 | 10.0 | 35.5 | 0 | 17 | 13.0 | 7.9 | 39.3 | 0 | 13 |
| Mean | 8 | 11.6 | 23.6 | NA | NA | 69.8 | 17.2 | 10.6 | 38.0 | 0 | 17 | 18.9 | 11.2 | 40.5 | 0 | 15 | |
| SEM | 1 | 0.4 | 2.3 | NA | NA | 1.3 | 0.8 | 0.4 | 2.3 | 0 | 1 | 2.2 | 1.2 | 2.2 | 0 | 1 | |
| hESC-CM | |||||||||||||||||
| P22 | F | 15y 7mo | 7.0 | 18.7 | 5.7 | 23.0 | 75 | 13.2 | 8.6 | 34.5 | 0 | 31 | 12.3 | 6.6 | 46.3 | 14 | 26 |
| P23 | F | 11y 6mo | 10.7 | 23.0 | 14.8 | 133.6 | 70 | 16.1 | 9.6 | 40.1 | 0 | 15 | 13.3 | 6.5 | 51.1 | 67 | 10 |
| P24 | F | 12y 2mo | 9.5 | 19.9 | 10.3 | 88.9 | 66 | 15.2 | 9.9 | 34.7 | 0 | 25 | 16.1 | 8.8 | 45.6 | 0 | 20 |
| P25 | F | 6y 7mo | 5.2 | 16.6 | ND | ND | 64 | 11.7 | 6.6 | 43.5 | 0 | 17 | 13.8 | 6.1 | 55.8 | 10 | 11 |
| P39 | F | 14y 6 mo | 9.2 | 21.5 | 15.6 | 115.6 | 58 | 13.7 | 7.6 | 44.0 | 0 | 16 | 11.2 | 5.5 | 51.0 | 18 | 13 |
| Mean | 11 | 8.6 | 19.9 | 11.6 | 90.3 | 66.6 | 14.0 * | 8.5* | 39.4 | 0 | 21 | 13.3* | 6.7** | 50.0* | 22 | 16 | |
| SEM | 2 | 0.9 | 1.1 | 2.3 | 21.0 | 2.9 | 0.8 | 0.6 | 2.1 | 0 | 3 | 0.8 | 0.6 | 1.9 | 12 | 3 | |
All hESC-CMs for these studies were derived from the H7 line.
NA, not applicable or not available
ND, Not detected. Graft was rejected at 5 weeks post-engraftment due to damage to intravenous catheter and interruption of immunosuppression. Not included in graft size calculations.
Infarcted LVTh, infarcted left ventricular wall systolic thickening
*
p< 0.05 control vs. hESC-CM treated
**
p < 0.01 control vs. hESC-CM treated