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. Author manuscript; available in PMC: 2019 Jan 11.
Published in final edited form as: MOJ Immunol. 2018 Mar 16;6(2):34–42.

Figure 2.

Figure 2

Mechanisms of infiltration and accumulation of Tregs in the tumor microenvironment: (1) Tregs are recruited to tumor from the periphery by chemokines e.g. CCL28 or CCL12; (2) Within the tumor microenvironment Tregs can be expanded by IL-2 administration; (3) Tumor derived TGF-β can covert naïve CD4+ T cells into Tregs.