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. 2018 Dec 31;14(12):e1007799. doi: 10.1371/journal.pgen.1007799

Table 1. Genetic colocalization of placenta eQTLs with birth weight, childhood obesity and childhood BMI GWAS loci.

Trait Gene ID Gene Symbol COLOC Posterior Probability
H0 H1 H2 H3 H4
Birth Weight
ENSG00000123104 ITPR2* 2.3E-07 1.2E-04 3.8E-05 1.9E-02 9.8E-01
ENSG00000107679 PLEKHA1* 3.2E-19 2.9E-04 3.3E-17 2.8E-02 9.7E-01
ENSG00000164532 TBX20* 1.5E-29 4.1E-05 2.8E-26 7.7E-02 9.2E-01
ENSG00000144401 METTL21A* 5.7E-06 7.8E-03 5.9E-05 8.0E-02 9.1E-01
ENSG00000006282 SPATA20* 8.7E-44 3.9E-02 1.1E-43 5.1E-02 9.1E-01
ENSG00000153214 TMEM87B* 3.4E-03 2.2E-02 1.1E-02 6.7E-02 9.0E-01
ENSG00000170889 RPS9 1.5E-04 6.1E-02 1.3E-04 5.3E-02 8.8E-01
ENSG00000092036 HAUS4* 1.9E-04 6.6E-02 3.1E-04 1.0E-01 8.3E-01
Childhood Obesity
ENSG00000213214 ARHGEF35 8.2E-03 3.4E-02 3.4E-03 1.3E-02 9.4E-01
ENSG00000085063 CD59 7.6E-03 6.6E-02 1.3E-03 1.0E-02 9.1E-01
ENSG00000138031 ADCY3* 1.2E-10 8.7E-07 1.4E-05 9.5E-02 9.0E-01
ENSG00000198793 MTOR 3.1E-02 1.5E-02 1.1E-01 5.1E-02 8.0E-01
ENSG00000150403 TMCO3 3.8E-03 1.8E-01 9.7E-04 4.4E-02 7.7E-01
ENSG00000010030 ETV7 2.6E-24 2.2E-01 1.3E-25 1.1E-02 7.7E-01
Childhood BMI
ENSG00000165238 WNK2 4.5E-03 4.5E-03 9.6E-02 9.5E-02 8.0E-01

* These genes were also identified in MetaXcan analysis (Table 2);

Genes of COLOC Posterior Probability of H4≥ 0.75 were presented