Table 1. Genetic colocalization of placenta eQTLs with birth weight, childhood obesity and childhood BMI GWAS loci.
Trait | Gene ID | Gene Symbol | COLOC Posterior Probability† | ||||
---|---|---|---|---|---|---|---|
H0 | H1 | H2 | H3 | H4 | |||
Birth Weight | |||||||
ENSG00000123104 | ITPR2* | 2.3E-07 | 1.2E-04 | 3.8E-05 | 1.9E-02 | 9.8E-01 | |
ENSG00000107679 | PLEKHA1* | 3.2E-19 | 2.9E-04 | 3.3E-17 | 2.8E-02 | 9.7E-01 | |
ENSG00000164532 | TBX20* | 1.5E-29 | 4.1E-05 | 2.8E-26 | 7.7E-02 | 9.2E-01 | |
ENSG00000144401 | METTL21A* | 5.7E-06 | 7.8E-03 | 5.9E-05 | 8.0E-02 | 9.1E-01 | |
ENSG00000006282 | SPATA20* | 8.7E-44 | 3.9E-02 | 1.1E-43 | 5.1E-02 | 9.1E-01 | |
ENSG00000153214 | TMEM87B* | 3.4E-03 | 2.2E-02 | 1.1E-02 | 6.7E-02 | 9.0E-01 | |
ENSG00000170889 | RPS9 | 1.5E-04 | 6.1E-02 | 1.3E-04 | 5.3E-02 | 8.8E-01 | |
ENSG00000092036 | HAUS4* | 1.9E-04 | 6.6E-02 | 3.1E-04 | 1.0E-01 | 8.3E-01 | |
Childhood Obesity | |||||||
ENSG00000213214 | ARHGEF35 | 8.2E-03 | 3.4E-02 | 3.4E-03 | 1.3E-02 | 9.4E-01 | |
ENSG00000085063 | CD59 | 7.6E-03 | 6.6E-02 | 1.3E-03 | 1.0E-02 | 9.1E-01 | |
ENSG00000138031 | ADCY3* | 1.2E-10 | 8.7E-07 | 1.4E-05 | 9.5E-02 | 9.0E-01 | |
ENSG00000198793 | MTOR | 3.1E-02 | 1.5E-02 | 1.1E-01 | 5.1E-02 | 8.0E-01 | |
ENSG00000150403 | TMCO3 | 3.8E-03 | 1.8E-01 | 9.7E-04 | 4.4E-02 | 7.7E-01 | |
ENSG00000010030 | ETV7 | 2.6E-24 | 2.2E-01 | 1.3E-25 | 1.1E-02 | 7.7E-01 | |
Childhood BMI | |||||||
ENSG00000165238 | WNK2 | 4.5E-03 | 4.5E-03 | 9.6E-02 | 9.5E-02 | 8.0E-01 |
* These genes were also identified in MetaXcan analysis (Table 2);
† Genes of COLOC Posterior Probability of H4≥ 0.75 were presented