Figure 1.

Lack of vasodilatation to native GLP‐1 in rat mesenteric and human s.c. arteries without branches. (A, B) Representative original traces from the myograph experiments in rat mesenteric arterial segments. Both vessels relax to a sufficient level when adding ACh. (A) Time control contracted with phenylephrine (Phe). (B) Vessel contracted with phenylephrine and exposed to a single physiological concentration of GLP‐1. Concentration–response curves for GLP‐1 in (C) rat mesenteric arteries (n = 7) and (D) human s.c. arteries (n = 9). The results are means ± SEM.