Figure 3.
Lack of effect of native GLP‐1 and liraglutide on neurogenic contractions in rat mesenteric arteries. (A) Representative original traces showing contractions induced by EFS in the absence and in the presence of increasing concentrations (M) of native GLP‐1 and liraglutide. Squares mark stimulation intervals (10 s). The traces are each representative of 5–6 different experiments. (B) Enlargement of the responses showing area under the curve (AUC) at one control stimulation and after adding native GLP‐1 (10−8 M) and (C) average AUC for the contractions in experiments where vehicle (n = 6), GLP‐1 (n = 6) or liraglutide (n = 5) was added. AUC of the contractions is presented as percentage of an initial control stimulation. Data are presented as means ± SEM. Unpaired t‐test showed no significant difference between treatments.