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Nrf2 played a pivotal role in mitochondrial protection in rats subjected to pMCAO. Nrf2 was knocked down by si‐Nrf2 in rats (n = 5) (A). Neurological score (B) and infarct volume (C, D) were evaluated (n = 5). Mitochondrial structure was observed by TEM (n = 5) (E). Mitochondrial respiration was determined by Oxygraph‐2k (n = 5) (F). Mitochondrial health was determined by fluorescence dye resazurin (n = 5) (G). Data are expressed as the mean ± SD and were analysed by ANOVA. *P < 0.05.
