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p62 played a pivotal role in the activation of Nrf2 pathway. p62 was knocked down by si‐p62 in both PC12 cell (A) and rats (C) (n = 5). Translocation of Nrf2 to the nucleus in PC12 cells was determined by immunofluorescence (n = 5) (B). The expression of n‐Nrf2 in rats was detected by Western blotting (n = 5) (D). Data are expressed as the mean ± SD and were analysed by ANOVA. *P < 0.05. n‐Nrf2, nucleus‐Nrf2.
