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Nef has a protective effect on mitochondria through activation of the p62–Keap1–Nrf2 pathway in cerebral ischaemia. Upon the onset of the ischaemic stroke, the mitochondria were damaged. Nef increased the translocation of Nrf2 to the nucleus through the activation of the p62–Keap1–Nrf2 pathway and further rescued mitochondria.
