Table 1.

Statistical analysis of the correlation between activities of flucloxacillin (FLX) hydroxylation and isoenzyme specific reactions catalysed by HLM from 16 different donors

Isoenzyme‐specific reaction	CYP	10 μM FLX		100 μM FLX
		Pearson's r	P‐value	Pearson's r	P‐value
Phenacetin O‐deethylation	CYP1A2	0.04	0.87	0.10	0.70
Coumarin 7‐hydroxylation	CYP2A6	0.45	0.078	0.45	0.093
Buproprion hydroxylation	CYP2B6	0.16	0.54	0.49	0.16
Amodiaquine N‐deethylation	CYP2C8	0.50	0.051	0.044	0.87
Diclofenac 4′‐hydroxylation	CYP2C9	0.78	0.0004	0.58	0.019
Mephenytoin 4′‐hydroxylation	CYP2C19	0.45	0.079	−0.059	0.83
Bufuralol 1‐hydroxylation	CYP2D6	0.15	0.59	−0.069	0.80
Chlorzoxazone 6‐hydroxylation	CYP2E1	0.42	0.10	0.36	0.17
Midazolam 1′‐hydroxylation	CYP3A4	0.58	0.012	0.48	0.061
Testosterone 6β‐hydroxylation	CYP3A4	0.69	0.003	0.39	0.14