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. Author manuscript; available in PMC: 2020 Jan 10.
Published in final edited form as: Cell. 2018 Dec 6;176(1-2):227–238.e20. doi: 10.1016/j.cell.2018.11.002

Figure 1: The basic functional modules of an epigenetic regulatory system.

Figure 1:

(1) Initiate: “initiators” establish chromatin modi fications at sequence-specific locations; (2) Read Out: “reader” proteins recognize modifications and mediate recruitment of regulators to establish transcriptional states; (3) Propagate: these states are propagated in the absence of the initial stimulus by read-write positive feedback mechanisms, whereby recognition of pre-existing marks is coupled to the placement of new modifications.