Table 2.
Renal expression of mRNAs for genes related to oxidative stress or hypoxia in Aqp11-/- mice.
| Gene | Fold change | p value | Gene | Fold change | p-value |
|---|---|---|---|---|---|
| Adm | 2.88 | 0.014 | Hnf4a | 1.18 | 0.690 |
| Agt | 3.64 | 0.006 | Hyou1 | 2.21 | 0.039 |
| Angptl4 | 1.72 | 0.039 | Igfbp1 | − 1.95 | 0.241 |
| App | 1.85 | 0.084 | Ing4 | 2.02 | 0.032 |
| Arnt | 3.06 | 0.013 | Keap1 | 3.46 | 1.62E-04 |
| Arnt2 | 3.34 | 0.023 | Mb | ND | |
| Atp1b1 | 1.59 | 0.225 | Mtor | 1.72 | 0.145 |
| Bhlhe40 | 4.14 | 0.026 | Nos1 | ND | |
| Birc2 | 2.90 | 0.102 | Nos3 | 4.31 | 0.019 |
| Camk2g | 2.28 | 0.038 | Notch1 | 5.48 | 0.010 |
| Casp1 | 5.89 | 0.086 | Nox2 | 23.61 | 0.008 |
| Cat | − 1.07 | 0.699 | Nox4 | 1.04 | 0.871 |
| Col18a1 | 7.04 | 0.010 | Nrf2 | 4.38 | 0.001 |
| Ddit4l | 2.53 | 0.011 | p22phox | 1.36 | 0.333 |
| Dusp1 | 3.07 | 0.008 | p40phox | 33.17 | 0.019 |
| Edn1 | 13.31 | 0.056 | p47phox | 44.66 | 0.028 |
| Ednra | 11.49 | 0.005 | p67phox | 14.97 | 0.009 |
| Egf | − 1.75 | 0.405 | Pik3ca | 1.49 | 0.230 |
| Egln1 | 1.73 | 0.102 | Plagl2 | 4.60 | 0.017 |
| Egln2 | 1.71 | 0.130 | Prl4a1 | ND | |
| Egln3 | 3.71 | 0.029 | Pten | 1.86 | 0.098 |
| Ep300 | 2.40 | 0.054 | Rb1 | 2.40 | 0.048 |
| Epas1 | 2.89 | 0.020 | Sim1 | 2.04 | 0.083 |
| Epo | ND | Sim2 | 2.06 | 0.060 | |
| Erbb2 | 1.54 | 0.268 | Slc2a8 | 1.79 | 0.081 |
| Gpx3 | 1.04 | 0.880 | Sod1 | − 1.11 | 0.755 |
| Gsta1 | 1.06 | 0.805 | Sod2 | − 1.08 | 0.700 |
| Hif1a | 2.66 | 0.013 | Sod3 | 1.28 | 0.189 |
| Hif1an | 2.61 | 0.034 | Sp1 | 2.32 | 0.071 |
| Hif3a | ND | Tgfbr2 | 4.18 | 0.049 | |
| Hmox1 | 5.69 | 0.002 | Wt1 | 1.08 | 0.874 |
ND: not detected.