Table 3.
Top 15 canonical pathways.
| Ingenuity Canonical Pathway | -log(p value) | Ratio | z-score | Molecules |
|---|---|---|---|---|
| Hypoxia Signaling in the Cardiovascular System | 8.92 | 0.0811 | 1.000 | ARNT, EDN1, EP300, HIF1AN, HIF1A, NOS3 |
| HIF1α Signaling | 7.64 | 0.0500 | NC | ARNT, EDN1, EGLN3, EP300, HIF1A, NOS3 |
| Osteoarthritis Pathway | 7.55 | 0.0323 | 0.816 | CASP1, EP300, EPAS1, HIF1A, NOTCH1, SP1, TGFBR2 |
| Molecular Mechanisms of Cancer | 5.87 | 0.0182 | NC | BIRC2, CAMK2G, EP300, HIF1A, NOTCH1, RB1, TGFBR2 |
| Aryl Hydrocarbon Receptor Signaling | 5.61 | 0.0342 | 0.447 | ARNT, EP300, NFE2L2 (NRF2), RB1, SP1 |
| Xenobiotic Metabolism Signaling | 5.39 | 0.0207 | NC | ARNT, CAMK2G, EP300, HMOX1, KEAP1, NFE2L2 (NRF2) |
| Renal Cell Carcinoma Signaling | 5.11 | 0.0471 | NC | ARNT, EGLN3, EP300, HIF1A |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | 5.09 | 0.0267 | NC | AGT, COL18A1, EDN1, EDNRA, TGFBR2 |
| Endothelin-1 Signaling | 4.89 | 0.0244 | 2.236 | CASP1, EDN1, EDNRA, HMOX1, NOS3 |
| Pancreatic Adenocarcinoma Signaling | 4.52 | 0.0333 | NC | HMOX1, NOTCH1, RB1, TGFBR2 |
| NRF2-mediated Oxidative Stress Response | 3.72 | 0.0207 | 1.000 | EP300, HMOX1, KEAP1, NFE2L2 (NRF2) |
| Production of Nitric Oxide and Reactive Oxygen Species in Macrophages | 3.66 | 0.0200 | 2.000 | CYBB (NOX2), NCF1 (p47phox), NCF2 (p67phox), NCF4 (p40phox) |
| Leukocyte Extravasation Signaling | 3.52 | 0.0184 | NC | CYBB (NOX2), NCF1 (p47phox), NCF2 (p67phox), NCF4 (p40phox) |
| Protein Kinase A Signaling | 3.48 | 0.0123 | 1.342 | CAMK2G, DUSP1, EP300, NOS3, TGFBR2 |
| VEGF Signaling | 3.24 | 0.0275 | NC | ARNT, HIF1A, NOS3 |
Ratio, ratio of the number of molecules mapped into the canonical pathway in our mRNA dataset relative to the total number of molecules in the pathway; z-score, the value indicating whether any given pathway is activated or inhibited; Molecules, the molecules in our mRNA dataset which map to the canonical pathways; NC, not calculated.