Figure 4.

Tumor-free Survival in Response to rAAV-CEA Vaccine Plus pGM-CSF

Following rAAV-CEA vaccination and application of pGM-CSF at the site of vector administration, when optimal CEA expression was achieved, mice were challenged with CEA-expressing, syngeneic MC38-CEA cells (4 × 10⁵) in the flank region. Tumor-free survival of naive, rAAV-GFP + pGM-CSF, or rAAV-CEA + pGM-CSF mice was recorded well beyond the time when mice in control groups had developed tumors (n = 5). **p < 0.01.