Table 1.

Simplified description of the information collected by the Italian MS Register with indications of the mandatory variables included in the MDS (in bold) and the optional variables (in italic). A detailed description of the MDS variables is reported in Appendix 1

Section	Sub-Section	Description
Baseline	Clinical center	Identification
	Patient	Identification and encryption of personal data State of Life Record creation date
	Onset MS	Date, symptoms, course (including RIS)
	Diagnosis	Date, Mc Donald Criteria 2010 and 2017 [8, 9]
Follow-up (FU)	Visits	Date, EDSS, course
	Relapses	Date, duration, functional systems involved, severity, recovery, steroid treatment
	Treatments	Start date, end date, dosage, administration routes, disease modifying or symptomatic therapies, discontinuation cause (if applicable)
	Adverse events	Reporting severe adverse events and adverse events (using MedDRA coding system)
Paraclinical tests	Magnetic Resonance Imaging	Date, CNS region, presence and number of T2, T1 and, T1 Gd + lesions, McDonald’s Criteria (2017) for space and time dissemination
	Cerebrospinal fluid	Date, routine, oligoclonal bands (presence/absence)
	Evoked potentials	Date, visual evoked potentials(VEP), upper and lower somatosensory and motor evoked potentials (SEP and MEP), brainstem auditory evoked potentials (BAEP)
	Laboratory tests	Date, routine, hematologic, virological, immunological, thyroid function
Clinical events	History	Family history, pregnancies, comorbidities