Table 2.

Performance indicators

Score	Optimal reference requirement	Requirement calculation mode	Assessment of the data quality score (quality metrics)
Update Center adherence to periodic central database update	Participating centers are required to upload data to the central server every 6 months	Interval between the update report date and the last upload date	Within 6 months 5 points > 6 months and ≤ 1 year 4 points > 1 year and ≤ 2 years 3 points > 2 years and ≤ 3 years 2 points Over 3 years: 1 point
N. Patients-year Sample size by center	Number of patients-year in the top quintile	The number of patients per year is calculated as the sum of the follow-up years* of each patient *Interval in years between last and first visit date recorded	Attribution based on quintile distribution: Within V quintile 5 points Within IV quintile 4 points Within III quintile 3 points Within II quintile 2 points Within I quintile 1 point
Patients with FUP ≥ 5 years Sample size by center with prospective clinical follow-up ≥ 5 years	% of patients with follow-up ≥ 5 years per center > 80%.	% of patients with follow-up ≥ 5 years per center	> 80% and ≤ 100% 5 points > 60% and ≤ 80% 4 points > 40% and ≤ 60% 3 points > 20% and ≤ 40% 2 points > 0% and ≤ 20% 1 point
Active patients Patients in active status, i.e. at least one visit and/or contact with the center in the last two years	% of patients in active status per center > 80%	% of patients in active status per center	> 80% and ≤ 100% 5 points > 60% and ≤ 80% 4 points > 40% and ≤ 60% 3 points > 20% and ≤ 40% 2 points > 0% and ≤ 20% 1 point
VISIT every 6 months Semi-annual visit rates	At least one visit every 6 months in the follow-up period in >80% of patients in each center	% of patients with at least one visit every 6 months in the follow-up period for center	> 80% and ≤ 100% 5 points > 60% and ≤ 80% 4 points > 40% and ≤ 60% 3 points > 20% and ≤ 40% 2 points > 0% and ≤ 20% 1 point
EDSS every 6 months Semi-annual EDSS assessment rates	At least one EDSS assessment every 6 months in the follow-up period in > 80% of patients in each center	% of patients with at least one EDSS assessment every 6 months in the follow-up period for center	> 80% and ≤ 100% 5 points > 60% and ≤ 80% 4 points > 40% and ≤ 60% 3 points > 20% and ≤ 40% 2 points > 0% and ≤ 20% 1 point
I° visit within I°year from onset First visit within 1 year of the disease onset	At least one visit within one year of the disease onset in >80% of patients in each center	% of patients with at least one visit within 1 year of the disease onset for center	> 80% and ≤ 100% 5 points > 60% and ≤ 80% 4 points > 40% and ≤ 60% 3 points > 20% and ≤ 40% 2 points > 0% and ≤ 20% 1 point