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. 2019 Jan 11;9:75. doi: 10.1038/s41598-018-36171-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrasonographic images of a PTC patient with (A,B) and without (C,D) cervical lymph node metastasis. (A) A nodule with certain malignant signs, such as hypoechogenicity, irregular shape, ill-defined margin, multiple microcalcification and capsule invasion; (B) CDFI showed rich blood flow in and around the nodule (A). (C) A hypoechoic nodule in the middle of the right thyroid, smaller than that in (A), with regular shape, defined margin, and no signs of capsule invasion; (D) CDFI showed lack of the blood flow signals, compared with that in (B). CDFI: Color Doppler Flow Imaging.